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  • Voclosporin
    • DMSO : ≥ 50 mg/mL (41.17 mM)
    货号: abs822246
    CAS号: 515814-01-4
    分子式: C63H111N11O12
    分子量: 1214.62
    产品说明书
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    货号-规格 货期 价格 数量
    abs822246-5mg 4周 ¥8600.00
    - +
    abs822246-25mg 4周 ¥25799.00
    - +
    大包装询价
    产品描述
    描述
    Voclosporin is a calcineurin (CN) inhibitor.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    基本信息
    别名
    DMSO : ≥ 50 mg/mL (41.17 mM)
    可溶性/溶解性
    DMSO : ≥ 50 mg/mL (41.17 mM)
    生物活性
    靶点
    Calcineurin
    In vitro(体外研究)
    This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.
    In vivo(体内研究)
    All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).
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