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  • Telmisartan

    • 替米沙坦
    货号: abs815922
    CAS号: 144701-48-4
    分子式: C33H30N4O2
    分子量: 514.62
    产品说明书
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    货号-规格 货期 价格 数量
    abs815922-50mg 现货 ¥573.00
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    abs815922-500mg 现货 ¥2409.00
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    大包装询价
    产品描述
    描述

    Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    替米沙坦
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    DMSO 10.3 mg/mL (20 mM)
    生物活性
    靶点
    angiotensin II receptor
    In vitro(体外研究)
    Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes.
    In vivo(体内研究)
    Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet.
    参考文献
    参考文献
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