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  • TD139

    货号: abs819066
    CAS号: 1450824-22-2
    分子式: C28H30F2N6O8S
    分子量: 648.64
    产品说明书
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    货号-规格 货期 价格 数量
    abs819066-1mg 1-2周 ¥2646.00
    - +
    abs819066-5mg 1-2周 ¥7938.00
    - +
    大包装询价
    产品描述
    描述
    TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO
    生物活性
    靶点
    Others
    In vitro(体外研究)
    TD139 is a novel synthetic inhibitor of galectin-3. TD139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N.
    In vivo(体内研究)
    In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and preventes the apoptosis of liver-infiltrating MNCs.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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