SPI 112
- SPI-112
货号: abs820097
货号-规格 | 货期 | 价格 | 数量 |
abs820097-10mg | 1-2周 | ¥500.00 | - + |
abs820097-50mg | 1-2周 | ¥1500.00 | - + |

产品描述 | ||
描述 | SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2. | |
纯度 | 97% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | SPI-112 | |
可溶性/溶解性 | DMSO : 50 mg/mL (106.73 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | SHP-2 | |
In vitro(体外研究) | SPI-112 has a polar -NO2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable. In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant KD of 1.30 µM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (Ki of 0.8 µM), suggesting that SPI-112 interacts with the catalytic site of SHP2. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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