SB 225002
- SB-225002
货号： abs810543
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810543-5mg | 现货 | ￥667.00 | - + |
| abs810543-10mg | 现货 | ￥735.00 | - + |
| abs810543-50mg | 现货 | ￥2205.00 | - + |
| abs810543-100mg | 现货 | ￥3405.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | SB-225002 | |
| 外观 | white to Light yellow Powder | |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (283.98 mM) | |
| 生物活性 | ||
| 靶点 | CXCR2 | |
| In vitro(体外研究) | In vitro, SB225002 inhibits GROα-stimulated calcium mobilization, and potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha. SB 225002 substantially reduces the levels of phosphorylated ERK1/2, and decreases cell proliferation in WHCO1 cells. SB225002 also shows the antitumor activity as a microtubule inhibitor. | |
| In vivo(体内研究) | In rabbits, SB225002 selectively blocks IL-8-induced neutrophil margination. In mouse intrahepatic cholangiocellular carcinoma model, SB225002 (1 mg/kg i.p.) suppresses the growth of transplanted subcutaneous tumors. In addition, SB225002 also displays long-lasting antinociceptive effects, and reduces TNBS-induced colitis in mouse models. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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危险品化学品经营许可证(不带存储) 许可证编号：沪(浦)应急管危经许[2022]202585(YS)
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