R-121919
- NBI30775; R 121919; R-121919
货号: abs811358
货号-规格 | 货期 | 价格 | 数量 |
abs811358-5mg | 4周 | ¥2668.00 | - + |
abs811358-10mg | 4周 | ¥4245.00 | - + |

产品描述 | ||
描述 | R121919 is a potent small-molecule CRF1 receptor antagonist. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | NBI30775; R 121919; R-121919 | |
可溶性/溶解性 | DMSO: 6.2 mg/mL (Need ultrasonic) | |
生物活性 | ||
靶点 | CRFR | |
In vitro(体外研究) | R121919 is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor (Ki=2–5 nM) and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types. | |
In vivo(体内研究) | R121919 reduces measures of both anxiety and depression in the depressed patients. R121919 dose dependently decreases adrenocorticopin hormone and corticosterone responses to restraint stress in rats. Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10 mg/kg R121919 are 9 and 25%, respectively. R121919 reduces levels of anxiety in mice with a steep dose-response curve. Molecules such as GR, MR, BAG-1 and AP-1 have been identified as some of the drug's intracellular targets. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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