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  • PTC-209
    • PTC209; PTC 209
    货号: abs810705
    CAS号: 315704-66-6
    分子式: C17H13Br2N5OS
    分子量: 495.19
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810705-5mg 现货 ¥1055.00
    - +
    abs810705-10mg 现货 ¥1597.00
    - +
    abs810705-50mg 现货 ¥5418.00
    - +
    abs810705-100mg 现货 ¥7740.00
    - +
    大包装询价
    产品描述
    描述

    PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    PTC209; PTC 209
    外观
    Powder
    可溶性/溶解性
    DMSO 99 mg/mL (199.92 mM)





    生物活性
    靶点
    BMI-1
    In vitro(体外研究)
    PTC-209 inhibits both the UTR-mediated reporter expression and endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 decreases colorectal tumor cell growth in a BMI-1-dependent way. In addition, PTC-209 impairs colorectal cancer-initiating cells (CICs) through irreversible growth inhibition.
    In vivo(体内研究)
    PTC-209 (60 mg/kg/day, s.c.) effectively inhibits BMI-1 production in tumor tissue, and halts growth of preestablished tumors in mice bearing primary human colon cancer xenograft, human colon cancer cell lines LIM1215 or HCT116 xenografts. PTC-209 also reduces the frequency of functional colorectal CICs in vivo.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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