PTC-209
- PTC209; PTC 209
货号： abs810705
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810705-5mg | 现货 | ￥1055.00 | - + |
| abs810705-10mg | 现货 | ￥1597.00 | - + |
| abs810705-50mg | 现货 | ￥5418.00 | - + |
| abs810705-100mg | 现货 | ￥7740.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | PTC209; PTC 209 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO 99 mg/mL (199.92 mM) | |
| 生物活性 | ||
| 靶点 | BMI-1 | |
| In vitro(体外研究) | PTC-209 inhibits both the UTR-mediated reporter expression and endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 decreases colorectal tumor cell growth in a BMI-1-dependent way. In addition, PTC-209 impairs colorectal cancer-initiating cells (CICs) through irreversible growth inhibition. | |
| In vivo(体内研究) | PTC-209 (60 mg/kg/day, s.c.) effectively inhibits BMI-1 production in tumor tissue, and halts growth of preestablished tumors in mice bearing primary human colon cancer xenograft, human colon cancer cell lines LIM1215 or HCT116 xenografts. PTC-209 also reduces the frequency of functional colorectal CICs in vivo. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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