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  • Protease-Activated Receptor-2, amide
    • 蛋白酶活化的受体-2,酰胺 ;SLIGKV-NH2
    货号: abs813066
    CAS号: 190383-13-2
    分子式: C28H54N8O7
    分子量: 614.78
    产品说明书
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    货号-规格 货期 价格 数量
    abs813066-5mg 1-2周 ¥772.00
    - +
    abs813066-25mg 1-2周 ¥2426.00
    - +
    大包装询价
    产品描述
    描述

    Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.  

    来源
    合成
    序列
    Ser-Leu-Ile-Gly-Lys-Val-NH2
    纯度
    ≥98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    蛋白酶活化的受体-2,酰胺 ;SLIGKV-NH2
    外观
    White lyophilised solid
    可溶性/溶解性
    H2O : 33.33 mg/mL (54.21 mM; Need ultrasonic)
    生物活性
    靶点
    PAR2
    In vitro(体外研究)
    It was reported that SLIGKV-NH2 (the PAR2 activating peptide), by inducing express of PAR2, could slightly enhanced mucin secretion by human bronchial epithelial cells in vitro. According to this study, compared to cells treated with a control peptide with reversed amino acid sequence, exposure of cells to SLIGKV-NH2 for 30 mins resulted in a weak but statistically significant increase in mucin secretion at concentrations of 100 and 1000M. In addition, SLIGKV-NH2 was demonstrated to accelerate cell cycle progression and stimulate the growth of HepG2 cells.
    In vivo(体内研究)
    The ability of PAR2 agonists to induce contractile responses was investigated in vivo. It was found that mouse PAR2 activating (SLIGRL-NH2) and human PAR2 activating (SLIGKV-NH2) peptides triggered a concentration-dependent contractile response in guinea-pig gallbladder.
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