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  • PF-3716556
    • PF03716556;PF 03716556
    货号: abs816320
    CAS号: 928774-43-0
    分子式: C22H26N4O3
    分子量: 394.47
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816320-5mg 1-2周 ¥536.00
    - +
    abs816320-10mg 1-2周 ¥965.00
    - +
    abs816320-50mg 1-2周 ¥3747.00
    - +
    abs816320-100mg 1-2周 ¥6745.00
    - +
    大包装询价
    产品描述
    描述

    PF-03716556 is a potent, and selective acid pump antagonist with pIC50 of 6.026, 6.038 and 6.009 at pH 6.4 for the inhibition of H+/K+-ATPase activity of porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 is used for the treatment of gastroesophageal reflux disease. PF-03716556 is highly selective for H+, K+-ATPase in vitro. PF-03716556 displays no activity at Na+, K+-ATPase. PF-03716556 inhibits gastric acid secretion in rat and dog models. PF-03716556 has no species differences among the porcine, canine and human enzymes. PF-03716556 produced greater inhibition than revaprazan in both the in vitro (ion-tight assay) and in vivo conditions. PF-03716556 offers long-lasting and maximal efficacy within 30 min of a single dosing with responses that are maintained for at least 5 days of repeated dosing with no signs of tolerance. PF-03716556 did not exhibit any biologically relevant activity against any of the tested more than 50 (e.g., adenosine receptor) receptors, ion channels, or enzymes expressed in naive tissues, cell lines and transfectants.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    PF03716556;PF 03716556
    可溶性/溶解性
    DMSO :39.5 mg/mL (100 mM)
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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