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  • NOD-IN-1
    • Compound 4
    货号: abs814387
    CAS号: 132819-92-2
    分子式: C18H17NO4S
    分子量: 343.4
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs814387-5mg 1-2周 ¥1764.00
    - +
    abs814387-10mg 1-2周 ¥2867.00
    - +
    abs814387-50mg 1-2周 ¥7497.00
    - +
    abs814387-100mg 1-2周 ¥12899.00
    - +
    大包装询价
    产品描述
    描述

    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Compound 4
    外观
    Powder
    可溶性/溶解性
    DMSO : 100 mg/mL (291.21 mM; Need ultrasonic)
    生物活性
    靶点
    NOD-like Receptor (NLR)
    In vitro(体外研究)
    NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.
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    • 实验方法 实验条件
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