N-Oxalylglycine
- N-草酰<乙二酰>甘氨酸；N-草酰甘氨酸；Oxalylglycine；NOG
货号： abs814563
| 货号-规格 | 货期 | 价格 | 数量 |
| abs814563-10mg | 现货 | ￥686.00 | - + |
| abs814563-50mg | 现货 | ￥1864.00 | - + |
| abs814563-100mg | 现货 | ￥2514.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs. | |
| 纯度 | ≥98% | |
| 使用方法 | Hygroscopic. | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | N-草酰<乙二酰>甘氨酸；N-草酰甘氨酸；Oxalylglycine；NOG | |
| 外观 | A crystalline solid | |
| 密度 | ~1.6 g/cm3 (Predicted) | |
| 折射率 | n20D 1.52 (Predicted) | |
| IC50 | PHD1: IC50 = 2.1 µM; PHD2 : IC50 = 5.6 µM; JMJD2E: IC50 = 24 µM; JMJD2A: IC50 = 250 µM; JMJD2C: IC50 = 500 µM | |
| PK值 | pKa: 2.83 (Predicted) | |
| Ki 数据 | Prolyl 4-hydroxylase alpha-1 subunit: Ki= 540 nM (rat); P4HA1: Ki= 8 µM (human); HIF-1α: Ki= 1.2 mM (human) | |
| 可溶性/溶解性 | Soluble in water, DMSO (~10 mg/ml, purged with inert gas), ethanol (~10 mg/ml, purged with inert gas), and DMF (~5 mg/ml, purged with inert gas). | |
| MDL | MFCD00913253 | |
| PubChem CID | 3080614 | |
| 生物活性 | ||
| 靶点 | JMJD2A,JMJD2C,JMJD2E,PHD1,PHD2 | |
| In vitro(体外研究) | NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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