首页 产品中心
  • N-Oxalylglycine

    • N-草酰<乙二酰>甘氨酸;N-草酰甘氨酸;Oxalylglycine;NOG
    货号: abs814563
    CAS号: 5262-39-5
    分子式: C4H5NO5
    分子量: 147.1
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs814563-10mg 现货 ¥686.00
    - +
    abs814563-50mg 现货 ¥1864.00
    - +
    abs814563-100mg 现货 ¥2514.00
    - +
    大包装询价
    产品描述
    描述

    N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.

    纯度
    ≥98%
    使用方法
    Hygroscopic.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    N-草酰<乙二酰>甘氨酸;N-草酰甘氨酸;Oxalylglycine;NOG
    外观
    A crystalline solid
    密度
    ~1.6 g/cm3 (Predicted)
    折射率
    n20D 1.52 (Predicted)
    IC50
    PHD1: IC50 = 2.1 µM; PHD2 : IC50 = 5.6 µM; JMJD2E: IC50 = 24 µM; JMJD2A: IC50 = 250 µM; JMJD2C: IC50 = 500 µM
    PK值
    pKa: 2.83 (Predicted)
    Ki 数据
    Prolyl 4-hydroxylase alpha-1 subunit: Ki= 540 nM (rat); P4HA1: Ki= 8 µM (human); HIF-1α: Ki= 1.2 mM (human)
    可溶性/溶解性
    Soluble in water, DMSO (~10 mg/ml, purged with inert gas), ethanol (~10 mg/ml, purged with inert gas), and DMF (~5 mg/ml, purged with inert gas).
    MDL
    MFCD00913253
    PubChem CID
    3080614
    生物活性
    靶点
    JMJD2A,JMJD2C,JMJD2E,PHD1,PHD2
    In vitro(体外研究)
    NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要提问

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0