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  • ML130 (Nodinitib-1)
    • ML130; CID-1088438
    货号: abs817782
    CAS号: 799264-47-4
    分子式: C14H13N3O2S
    分子量: 287.34
    产品说明书
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    货号-规格 货期 价格 数量
    abs817782-10mg 现货 ¥725.00
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    abs817782-50mg 现货 ¥2486.00
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    大包装询价
    产品描述
    描述

    ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    ML130; CID-1088438
    外观
    white to beige powder
    可溶性/溶解性
    DMSO : 28.7 mg/mL (100 mM)

    Ethanol : 2.9 mg/mL (10 mM)
    生物活性
    靶点
    NOD1; NOD2; TNF-α;
    In vitro(体外研究)
    ML130 has shown selective inhibition of NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity and is selected as a probe candidate molecule. ML130 is also confirmed in secondary assays by selectively inhibiting NOD1-dependent IL-8 secretion and also selectively inhibiting the NOD1-dependent pathway to NF-κB activation. In another research, ML130 is proved to cause conformational changes of NOD1 in vitro and alter NOD1 subcellular targeting in cells, providing chemical probes for interrogating mechanisms regulating NOD1 activity and tools for exploring the roles of NOD1 in various infectious and inflammatory diseases.
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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