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  • Kira8
  • 货号: abs821059
    CAS号: 1630086-20-2
    分子式: C31H29ClN6O3S
    分子量: 601.12
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs821059-5mg 4周 ¥2772.00
    - +
    abs821059-50mg 4周 ¥13860.00
    - +
    大包装询价
    产品描述
    描述
    Kira8 is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
    储存/保存方法
    store at -20℃ for one year(Powder)
    生物活性
    In vitro(体外研究)
    Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2.
    In vivo(体内研究)
    Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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