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  • JSH-23
  • JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II
  • 货号: abs810538
    CAS号: 749886-87-1
    分子式: C16H20N2
    分子量: 240.34
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810538-5mg 现货 ¥1174.00
    - +
    abs810538-10mg 现货 ¥1686.00
    - +
    abs810538-50mg 1-2周 ¥6027.00
    - +
    abs810538-100mg 1-2周 ¥8600.00
    - +
    大包装询价
    产品描述
    描述

    JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    别名
    JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II
    外观
    off-white Powder
    可溶性/溶解性

    DMSO : 45 mg/mL (187.2 mM)

    Ethanol :16 mg/mL (66.6 mM)
    生物活性
    靶点
    NF-κB
    In vitro(体外研究)
    JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.
    In vivo(体内研究)
    JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.
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