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  • (-)-Huperzine A (HupA)

    • (-)-石杉碱甲;Huperzine A
    货号: abs812082
    CAS号: 102518-79-6
    分子式: C15H18N2O
    分子量: 242.32
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    货号-规格 货期 价格 数量
    abs812082-2mg 现货 ¥491.00
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    abs812082-5mg 现货 ¥667.00
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    abs812082-10mg 现货 ¥1052.00
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    大包装询价
    产品描述
    描述

    (-)-Huperzine A (HupA)是一种有效的,高度特异性的,可逆acetylcholinesterase (AChE)(乙酰胆碱酯酶)抑制剂,Ki为7 nM,作用于G4 AChE比作用于G1 AChE选择性高200倍。

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    (-)-石杉碱甲;Huperzine A
    外观
    白色粉末
    可溶性/溶解性
    DMSO : 0.66 mg/mL (2.72 mM)
    生物活性
    靶点
    AChE (G4 form)
    In vitro(体外研究)
    (-)-Huperzine A is a novel alkaloid isolated from the Chinese herb Huperzia serrata. (-)-Huperzine A preferentially inhibits tetrameric AChE (G4 form). (-)-Huperzine A is more potent than tacrine, physostigmine, galanthamine, and rivastigmine with respect to inhibition of AChE activity, whereas HupA is the least potent BuChE inhibitor among the inhibitors. (-)-Huperzine A possesses the ability to protect cells against hydrogen peroxide, β-amyloid protein, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism.
    In vivo(体内研究)
    (-)-Huperzine A can ameliorate the learning and memory deficiency in animal models and AD patients. Its potentially beneficial actions include modification of β-amyloid peptide processing, reduction of oxidative stress, neuronal protection against apoptosis, and regulation of the expression and secretion of nerve growth factor (NGF) and NGF signaling. (-)-Huperzine A significantly inhibits AChE activity in the cortex, hippocampus, striatum, medial septum, medulla oblongata, cerebellum, and hypothalamus of rats that are killed 30 min following the administration of (-)-Huperzine A at several dose levels compared with the saline control.
    参考文献
    参考文献
    [1] Zhao Q, et al. Eur J Pharmacol, 2002, 455(2-3), 101-107.
    [2] Zhang HY, et al. Trends Pharmacol Sci, 2006, 27(12), 619-625.
    [3] Wang R, et al. Acta Pharmacol Sin, 2006, 27(1), 1-26.
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