GNE-7915
- GNE7915; GNE 7915
货号： abs810417
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810417-5mg | 1-2周 | ￥604.00 | - + |
| abs810417-10mg | 1-2周 | ￥1087.00 | - + |
| abs810417-50mg | 1-2周 | ￥3587.00 | - + |
| abs810417-100mg | 1-2周 | ￥6091.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | GNE7915; GNE 7915 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO 22 mg/mL warmed (49.61 mM) | |
| 生物活性 | ||
| 靶点 | LRRK2 ,LRRK2 | |
| In vitro(体外研究) | GNE-7915 is also a moderately potent 5-HT2B antagonist according to in vitro functional assays. GNE-7915 demonstrates excellent in vitro DMPK with minimal turnover in human hepatocytes. | |
| In vivo(体内研究) | In rats, GNE-7915 demonstrates excellent in vivo PK profiles with long half-lives, good oral exposure and high passive permeability. GNE-7915 (50 mg/kg i.p. or p.o.) results in concentration-dependent knockdown of pLRRK2 in the brain of BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
共 0 张，还能上传 8 张 提交
- 提示： 尊敬的客户您好，如果您对我们的产品有什么疑问或想要了解的，可以点击“我要咨询”按钮填写您的疑问。
提交不成功？请联系info@absin.cn。
Certificate of Analysis(COA)
促销资讯 更多
订购信息
您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商，请从以下的下拉列表中选择。
危险品化学品经营许可证(不带存储) 许可证编号：沪(浦)应急管危经许[2022]202585(YS)
营业执照(三证合一)