GNE-7915
- GNE7915; GNE 7915
货号: abs810417
货号-规格 | 货期 | 价格 | 数量 |
abs810417-5mg | 1-2周 | ¥604.00 | - + |
abs810417-10mg | 1-2周 | ¥1087.00 | - + |
abs810417-50mg | 1-2周 | ¥3587.00 | - + |
abs810417-100mg | 1-2周 | ¥6091.00 | - + |

产品描述 | ||
描述 | GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | GNE7915; GNE 7915 | |
外观 | Powder | |
可溶性/溶解性 | DMSO 22 mg/mL warmed (49.61 mM) | |
生物活性 | ||
靶点 | LRRK2 ,LRRK2 | |
In vitro(体外研究) | GNE-7915 is also a moderately potent 5-HT2B antagonist according to in vitro functional assays. GNE-7915 demonstrates excellent in vitro DMPK with minimal turnover in human hepatocytes. | |
In vivo(体内研究) | In rats, GNE-7915 demonstrates excellent in vivo PK profiles with long half-lives, good oral exposure and high passive permeability. GNE-7915 (50 mg/kg i.p. or p.o.) results in concentration-dependent knockdown of pLRRK2 in the brain of BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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