Genistein
促销商品- 酪氨酸蛋白激酶抑制剂，NPI 031L
货号： abs810004
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810004-5mg | 现货 | - + | |
| abs810004-10mg | 现货 | - + | |
| abs810004-50mg | 现货 | - + |
大包装询价| 产品描述 | ||
| 描述 | Genistein(NPI 031L)是豆制品中的植物雌激素，是PTK特异性抑制剂，能阻断EGF或胰岛素介导的NIH-3T3有丝分裂，IC50分别为12μM和19μM。 | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 酪氨酸蛋白激酶抑制剂，NPI 031L | |
| 外观 | off-white to Light yellow powder | |
| 可溶性/溶解性 | DMSO：54 mg/mL (199.82 mM) Ethanol：2 mg/mL (7.4 mM) | |
| 生物活性 | ||
| 靶点 | EGFR | |
| In vivo(体内研究) | In the present study, the effective dose of morphine caused a significant decrease in testis weight of mice compared to Saline group (p=0.00). Moreover, testis weight are significantly increase in treated animals with Genistein and Genistein plus morphine in all doses in comparison with morphine group (p=0.028). Morphine caused a significant decrease in the testosterone, LH and FSH hormones compared to saline group (p=0.00). In addition, the testosterone, LH and FSH hormones increased significantly in Genistein (p. Bisphenol A (BPA) treatment alone and combined with Genistein had no significant effect on the protein expression of LC3II and PPARα in liver of STD- or HFD-fed rats (P>0.05; P>0.05). Significant decreasing of the protein expression of PPARγ in liver is observed when Genistein is added to rats, compared to either HFD group or HFD-BPA group. | |
| 参考文献 | ||
| 参考文献 | [1] Akiyama T, et al. J Biol Chem, 1987, 262(12), 5592-5595.
[2] Linassier C, et al. Biochem Pharmacol, 1990, 39(1), 187-193. [3] Dang ZC, et al. J Biol Chem, 2003, 278(2), 962-967. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
