Genistein
促销商品- 酪氨酸蛋白激酶抑制剂,NPI 031L
货号: abs810004
货号-规格 | 货期 | 价格 | 数量 |
abs810004-5mg | 现货 | - + | |
abs810004-10mg | 现货 | - + | |
abs810004-50mg | 现货 | - + |

产品描述 | ||
描述 | Genistein(NPI 031L)是豆制品中的植物雌激素,是PTK特异性抑制剂,能阻断EGF或胰岛素介导的NIH-3T3有丝分裂,IC50分别为12μM和19μM。 | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 酪氨酸蛋白激酶抑制剂,NPI 031L | |
外观 | off-white to Light yellow powder | |
可溶性/溶解性 | DMSO:54 mg/mL (199.82 mM) Ethanol:2 mg/mL (7.4 mM) | |
生物活性 | ||
靶点 | EGFR | |
In vivo(体内研究) | In the present study, the effective dose of morphine caused a significant decrease in testis weight of mice compared to Saline group (p=0.00). Moreover, testis weight are significantly increase in treated animals with Genistein and Genistein plus morphine in all doses in comparison with morphine group (p=0.028). Morphine caused a significant decrease in the testosterone, LH and FSH hormones compared to saline group (p=0.00). In addition, the testosterone, LH and FSH hormones increased significantly in Genistein (p. Bisphenol A (BPA) treatment alone and combined with Genistein had no significant effect on the protein expression of LC3II and PPARα in liver of STD- or HFD-fed rats (P>0.05; P>0.05). Significant decreasing of the protein expression of PPARγ in liver is observed when Genistein is added to rats, compared to either HFD group or HFD-BPA group. | |
参考文献 | ||
参考文献 | [1] Akiyama T, et al. J Biol Chem, 1987, 262(12), 5592-5595.
[2] Linassier C, et al. Biochem Pharmacol, 1990, 39(1), 187-193. [3] Dang ZC, et al. J Biol Chem, 2003, 278(2), 962-967. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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