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  • Ganciclovir

    • 更昔洛韦;BW 759;2'-Nor-2'-deoxyguanosine
    货号: abs817965
    CAS号: 82410-32-0
    分子式: C9H13N5O4
    分子量: 255.23
    产品说明书
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    货号-规格 货期 价格 数量
    abs817965-50mg 1-2周 ¥309.00
    - +
    abs817965-100mg 1-2周 ¥497.00
    - +
    abs817965-200mg 1-2周 ¥860.00
    - +
    abs817965-500mg 1-2周 ¥1411.00
    - +
    大包装询价
    产品描述
    描述
    Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    更昔洛韦;BW 759;2'-Nor-2'-deoxyguanosine
    外观
    白色结晶性粉末
    可溶性/溶解性
    DMSO : 50 mg/mL (195.9 mM)
    生物活性
    靶点
    HSV
    In vitro(体外研究)
    Ganciclovir is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir.The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase.Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase.
    In vivo(体内研究)
    In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice.
    参考文献
    参考文献
    [1] Ladd B, O'Konek JJ, Ostruszka LJ, Shewach DS. Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir. Cancer Gene Ther. 2011;18(10):751-759.
    [2] Schnepf N, Corvo J, Pors MJ, Mazeron MC. Antiviral activity of ganciclovir and artesunate towards human cytomegalovirus in astrocytoma cells. Antiviral Res. 2011;89(2):186-188.
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