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  • FPS-ZM1

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    • FPS ZM1
    货号: abs810156
    CAS号: 945714-67-0
    分子式: C20H22ClNO
    分子量: 327.9
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810156-5mg 现货 ¥607.00 ¥182.00
    - +
    abs810156-10mg 现货 ¥856.00 ¥257.00
    - +
    abs810156-50mg 现货 ¥2911.00 ¥873.00
    - +
    abs810156-100mg 现货 ¥4488.00 ¥1346.00
    - +
    大包装询价
    产品描述
    描述

    FPS-ZM1 is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    FPS ZM1
    外观
    Powder
    可溶性/溶解性
    DMSO 65 mg/mL (198.26 mM)

    Ethanol 65 mg/mL (198.26 mM)


    生物活性
    靶点
    RAGE
    In vitro(体外研究)
    FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD.
    In vivo(体内研究)
    FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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