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  • Fluoxetine

    • 氟西汀;LY-110140
    货号: abs816684
    CAS号: 54910-89-3
    分子式: C17H18F3NO
    分子量: 309.33
    产品说明书
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    货号-规格 货期 价格 数量
    abs816684-25mg 现货 ¥612.00
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    abs816684-50mg 现货 ¥680.00
    - +
    abs816684-100mg 现货 ¥874.00
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    abs816684-200mg 现货 ¥1572.00
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    大包装询价
    产品描述
    描述

    Fluoxetine(LY110140) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    氟西汀;LY-110140
    外观
    白色粉末
    可溶性/溶解性
    Water : 50 mg/mL
    生物活性
    靶点
    MRP1;Sert (Sodium-dependent)
    In vitro(体外研究)
    Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration.
    In vivo(体内研究)
    Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone.
    参考文献
    参考文献
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