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  • Exendin-4 Acetate

    货号: abs818569
    CAS号: 914454-01-6
    分子式: C186H286N50O62S
    分子量: 4246.62
    产品说明书
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    货号-规格 货期 价格 数量
    abs818569-1mg 1-2周 ¥3175.00
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    abs818569-5mg 1-2周 询价
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    产品描述
    描述
    Exendin-4 Acetate, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    10 mM in H2O
    生物活性
    靶点
    Glucagon Receptor
    In vitro(体外研究)
    In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 μM at 48 hour.
    In vivo(体内研究)
    Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, insulin levels and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period. Animals treated with exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower insulin and leptin levels as well as lower HOMA values in rats. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO.
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    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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