ESI-09
- ESI 09
货号： abs817454
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817454-5mg | 1-2周 | ￥741.00 | - + |
| abs817454-10mg | 1-2周 | ￥1222.00 | - + |
| abs817454-25mg | 1-2周 | ￥2078.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. | |
| 纯度 | ＞98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | ESI 09 | |
| 外观 | faint yellow to dark orange powder | |
| 可溶性/溶解性 | DMSO : 33.1 mg/mL (100 mM) Ethanol : 6.6 mg/mL (20 mM) | |
| 生物活性 | ||
| 靶点 | EPAC2 ,EPAC1 | |
| In vitro(体外研究) | ESI-09, a novel non-cyclic nucleotide EPAC antagonist, that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. On the other hand, ESI-09 fails to suppress epidermal growth factor (EGF)-induced phosphorylation of Akt in AsPC1 cells. In pancreatic cancer cells, ESI-09 inhibits cells migration and invasion through decreasing 007-AM-induced cell adhesion dose-dependently. ESI-09 significantly reduces intracellular and total bacterial counts in human umbilical vein endothelial cells. ESI-09 effectively antagonizes Schwann cells (SC) differentiation induced by CPT-cAMP as well as the formation of myelin. In SC-neuron cultures, ESI-09 dramatically reduces the number of O1 positive and MBP positive SCs without compromising the health of the neurons or the SCs themselves. | |
| In vivo(体内研究) | ESI-09 (10 mg/kg/d, i.p.), via pharmacological inhibition of EPAC1, protects WT C57BL/6 mice from fatal SFG rickettsiosis. | |
| 参考文献 | ||
| 参考文献 | ||
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
