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  • Entecavir

    • 恩替卡韦;BMS200475;SQ34676
    货号: abs816498
    CAS号: 142217-69-4
    分子式: C12H15N5O3
    分子量: 277.28
    产品说明书
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    货号-规格 货期 价格 数量
    abs816498-5mg 1-2周 ¥634.00
    - +
    abs816498-10mg 1-2周 ¥1130.00
    - +
    abs816498-20mg 1-2周 ¥2034.00
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    大包装询价
    产品描述
    描述

    Entecavir(BMS200475; SQ34676) is a guanosine analogue that inhibits reverse transcription, DNA replication and transcription in the viral replication process; oral antiHBV drug.

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    恩替卡韦;BMS200475;SQ34676
    外观
    白色结晶粉末
    可溶性/溶解性
    DMSO : ≥44 mg/mL
    生物活性
    靶点
    HBV
    In vitro(体外研究)
    BMS-200475 has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h.
    In vivo(体内研究)
    Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks.
    参考文献
    参考文献
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