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  • Dexamethasone acetate
    • 醋酸地塞美松;Dexamethasone 21-acetate
    货号: abs813595
    CAS号: 1177-87-3
    分子式: C24H31FO6
    分子量: 434.5
    产品说明书
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    货号-规格 货期 价格 数量
    abs813595-50mg 1-2周 ¥695.00
    - +
    abs813595-100mg 1-2周 ¥827.00
    - +
    abs813595-200mg 1-2周 ¥1080.00
    - +
    abs813595-500mg 1-2周 ¥1709.00
    - +
    大包装询价
    产品描述
    描述

    Dexamethasone acetate是一种有效的糖皮质激素类合成物,属于类固醇药物。Dexamethasone用于很多炎症和自身免疫病的治疗,例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone也用在诊断方面,利用它能抑制垂体一肾上腺轴特性。Dexamethasone用于很多炎症和自身免疫病的治疗,例如风湿性关节炎和支气管痉挛。接受化疗的癌症病人服用dexamethasone去抵消部分化疗带来的副作用。Dexamethasone 也用在诊断方面,利用它能抑制垂体一肾上腺轴特性。

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    醋酸地塞美松;Dexamethasone 21-acetate
    外观
    白色粉末
    可溶性/溶解性
    Ethanol :16 mg/mL (36.8 mM)

    DMSO :81 mg/mL (186.4 mM)
    生物活性
    靶点
    interleukin receptor
    In vitro(体外研究)
    Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression.
    In vivo(体内研究)
    Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats.
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