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  • COH000

    货号: abs820909
    CAS号: 1534358-79-6
    分子式: C25H25NO5
    分子量: 419.47
    产品说明书
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    货号-规格 货期 价格 数量
    abs820909-10mg 1-2周 ¥1650.00
    - +
    abs820909-50mg 1-2周 ¥4950.00
    - +
    大包装询价
    产品描述
    描述
    COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO : 35.71 mg/mL (85.13 mM; Need ultrasonic)
    生物活性
    In vitro(体外研究)
    COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme.
    In vivo(体内研究)
    COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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