COH000
货号： abs820909
| 货号-规格 | 货期 | 价格 | 数量 |
| abs820909-10mg | 1-2周 | ￥1650.00 | - + |
| abs820909-50mg | 1-2周 | ￥4950.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro. | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 可溶性/溶解性 | DMSO : 35.71 mg/mL (85.13 mM; Need ultrasonic) | |
| 生物活性 | ||
| In vitro(体外研究) | COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme. | |
| In vivo(体内研究) | COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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