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  • Chelerythrine Chloride

    • 氯化白屈菜红碱;氯化白屈菜赤碱;盐酸白屈菜红碱
    货号: abs814674
    CAS号: 3895-92-9
    分子式: C21H18NO4•Cl
    分子量: 383.82
    产品说明书
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    货号-规格 货期 价格 数量
    abs814674-5mg 1-2周 ¥662.00
    - +
    abs814674-50mg 1-2周 ¥3749.00
    - +
    大包装询价
    产品描述
    描述

    Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.

    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    氯化白屈菜红碱;氯化白屈菜赤碱;盐酸白屈菜红碱
    外观
    yellow to orange Powder
    可溶性/溶解性
    DMSO : 4.35 mg/mL (11.33 mM; Need ultrasonic)
    MDL
    MFCD00060717
    生物活性
    靶点
    PKC
    In vitro(体外研究)
    Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaced Bax, a BH3-containing protein, from BclXL. Mammalian cells treated with Chelerythrine undergoes apoptosis with characteristic features that suggest involvement of the mitochondrial pathway. Chelerythrine treatment inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) activation. Moreover, the effects of chelerythrine on NO and cytokine TNF-α production can possibly be explained by the role of p38 MAPK and ERK1/2 in the regulation of inflammatory mediators expression. Chelerythrine shows cytotoxic effect on the human monocytic leukaemia cells with LD50 value of 3.46 μM. Two hours after LPS stimulation, cells influenced by sanguinarine and Chelerythrine significantly decline the CCL-2 expression by a factors of 3.5 and 1.9. Chelerythrine chloride significantly enhances the phosphorylation of ERK1/2 in a dose-dependent manner. In addition, chelerythrine chloride inhibits the phosphorylation of p38.
    In vivo(体内研究)
    Chelerythrine displays significant anti-inflammatory effects in experimentally induced mice endotoxic shock model in vivo through inhibition of LPS-induced tumor necrosis factor-alpha (TNF-α) level and nitric oxide (NO) production in serum. Chelerythrine chloride (5 mg/kg/day, i.p.) induces apoptosis of RCC cells without significant toxicity to mice. Chelerythrine Chloride treatment leads to a dose-dependent accumulation of p53.
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    • 实验方法 实验条件
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