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  • BML-277

    • Chk2 Inhibitor II; C 3742; BML277; BML 277
    货号: abs810266
    CAS号: 516480-79-8
    分子式: C20H14ClN3O2
    分子量: 363.8
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810266-5mg 1-2周 ¥662.00
    - +
    abs810266-10mg 1-2周 ¥902.00
    - +
    abs810266-50mg 1-2周 ¥3105.00
    - +
    abs810266-100mg 1-2周 ¥5588.00
    - +
    大包装询价
    产品描述
    描述

    BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Chk2 Inhibitor II; C 3742; BML277; BML 277
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 55 mg/mL
    生物活性
    靶点
    Chk2
    In vitro(体外研究)
    The CHK2 Inhibitor II shows 1,000-fold greater selectivity for the CHK2 serine/threonine kinase than for the Cdk1/B and CK1 kinases and was first discovered to be a potent, selective small molecule showing radioprotection towards human T cells. Different doses of CHK2 inhibitor II specifically inhibit CHK2 phosphorylation at Thr68 at different time course, but not CHK1 phosphorylation. Treatment with combination of CHK2 inhibitor II and ERK inhibitor results in substantially more apoptosis compared with treatment of either drug alone.
    In vivo(体内研究)
    SUDHL6 DLBCL xenografts mice treated every other day intraperitoneally with either vehicle, ERK inhibitor (5 mg kg−1), CHK2 inhibitor II (1 mg kg−1), or both ERK inhibitor and CHK2 inhibitor II for 20 days show no lethal toxicity, significant weight loss or any gross abnormalities. Both 5 mg/kg ERK inhibitor and 1 mg/kg CHK2 inhibitor II modestly inhibit tumour growth but combined treatment with ERK inhibitor and CHK2 inhibitor II results in a statistically significant suppression of tumour growth.
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    • 实验方法 实验条件
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