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  • BIO-Acetoxime

    • BIA;GSK3 Inhibitor X6-Bromoindirubin-3'-acetoxime
    货号: abs810193
    CAS号: 667463-85-6
    分子式: C18H12BrN3O3
    分子量: 398.21
    产品说明书
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    货号-规格 货期 价格 数量
    abs810193-5mg 1-2周 ¥854.00
    - +
    abs810193-10mg 1-2周 ¥1359.00
    - +
    abs810193-50mg 1-2周 ¥4657.00
    - +
    abs810193-100mg 1-2周 ¥7547.00
    - +
    大包装询价
    产品描述
    描述

    BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    BIA;GSK3 Inhibitor X6-Bromoindirubin-3'-acetoxime
    外观
    dark red to purple powder
    可溶性/溶解性
    DMSO : 20.83 mg/mL (52.31 mM; Need ultrasonic)
    生物活性
    靶点
    GSK-3α;GSK-3β
    In vitro(体外研究)
    BIO-acetoxime (BIA; Compound 13) is a potent and selective GSK-3α/β inhibitor, with IC50s of both 10 nM. BIO-acetoxime (BIA) shows weak effect on CDK5/p35 (IC50, 2.4 μM), CDK2/cyclin A (IC50, 4.3 μM), and CDK1/cyclin B (IC50, 63 μM). BIO-acetoxime (BIA) (5 μM and 10 μM) increases the viability of HSV-1-infected cells but shows little effect on morphology and viability of mockin-fected cells. Moreover, BIO-acetoxime (BIA) (0.625, 1.25, 2.5, 5, and 10 μM) significantly reduces the release of HSV-1 particles in OC3 cells, with an EC50 of 0.68 ± 0.28 μM. BIO-acetoxime (BIA) inhibits the expression of HSV-1 genes, and may not affect the nuclear targeting of HSV-1 capsids. In addition, delayed addition of BIO-acetoxime (BIA) also inhibits HSV-1 infection.
    In vivo(体内研究)
    BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration.
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    • 实验方法 实验条件
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