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  • Betahistine dihydrochloride
    • 盐酸倍他司汀
    货号: abs813517
    CAS号: 5579-84-0
    分子式: C8H12N2.2HCl
    分子量: 209.12
    产品说明书
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    货号-规格 货期 价格 数量
    abs813517-100mg 1-2周 ¥309.00
    - +
    abs813517-200mg 1-2周 ¥551.00
    - +
    abs813517-1g 1-2周 ¥992.00
    - +
    大包装询价
    产品描述
    描述

    在3 μM forskolin处理的CHO(H3R)细胞中, Betahistine 可以渐进性地增加 cAMP形成,在10 nM时达到最大效果,而当浓度高于10 nM时效果相反,会渐进性地抑制cAMP 形成。Betahistine 渐进性地降低CHO(H3R)细胞中A23187诱发的 [3H]花生四烯酸释放 (EC50=0.1 nM), 在30 nM 时效果最好,当浓度高于30 nM时效果相反,会增加A23187诱发的 [3H]花生四烯酸释放

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    盐酸倍他司汀
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    Ethanol :1 mg/mL (4.78 mM)

    DMSO :36 mg/mL (172.1 mM)

    Water :35 mg/mL (167.4 mM)
    生物活性
    靶点
    Histamine H3 receptor
    In vitro(体外研究)
    Betahistine progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast, at concentrations higher than 10 nM betahistine progressively inhibits cAMP formation in CHO(H3R) cells incubated with 3 μM forskolin. Betahistine progressively reduces A23187-evoked arachidonic acid release (EC50=0.1 nM) with a maximal effect, observed up to 30 nM A23187-evoked arachidonic acid release from CHO(H3R) cells. Betahistine progressively enhanced the release of A23187-evoked arachidonic acid from CHO(H3R) cells at concentrations higher than 30 nM.
    In vivo(体内研究)
    Betahistine ( Betahistine (16 mg twice per day for 3 months) has a significant effect on the frequency, intensity and duration of vertigo attacks, associated symptoms and the quality of life also are significantly improved in patients with Meniere's disease. Betahistine-dihydrochloride (16 mg tid and 48 mg tid) shows that the number of attacks per month decreased in both doses over time in Meni鑢e's disease. Betahistine (50 mg/kg) treatment induces symmetrical changes with up-regulation of histidine decarboxylase mRNA in the tuberomammillary nucleus and reduction of N-alpha-methylhistamine labeling in both the tuberomammillary nucleus, the vestibular nuclei complex and nuclei of the inferior olive in brain sections of cats.
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