- 盐酸倍他司汀
货号： abs813517
| 货号-规格 | 货期 | 价格 | 数量 |
| abs813517-100mg | 1-2周 | ￥309.00 | - + |
| abs813517-200mg | 1-2周 | ￥551.00 | - + |
| abs813517-1g | 1-2周 | ￥992.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | 在3 μM forskolin处理的CHO(H3R)细胞中， Betahistine 可以渐进性地增加 cAMP形成，在10 nM时达到最大效果，而当浓度高于10 nM时效果相反，会渐进性地抑制cAMP 形成。Betahistine 渐进性地降低CHO(H3R)细胞中A23187诱发的 [3H]花生四烯酸释放 (EC50=0.1 nM)， 在30 nM 时效果最好，当浓度高于30 nM时效果相反，会增加A23187诱发的 [3H]花生四烯酸释放 | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 别名 | 盐酸倍他司汀 | |
| 外观 | 白色或类白色结晶性粉末 | |
| 可溶性/溶解性 | Ethanol ：1 mg/mL (4.78 mM) DMSO ：36 mg/mL (172.1 mM) Water ：35 mg/mL (167.4 mM) | |
| 生物活性 | ||
| 靶点 | Histamine H3 receptor | |
| In vitro(体外研究) | Betahistine progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast, at concentrations higher than 10 nM betahistine progressively inhibits cAMP formation in CHO(H3R) cells incubated with 3 μM forskolin. Betahistine progressively reduces A23187-evoked arachidonic acid release (EC50=0.1 nM) with a maximal effect, observed up to 30 nM A23187-evoked arachidonic acid release from CHO(H3R) cells. Betahistine progressively enhanced the release of A23187-evoked arachidonic acid from CHO(H3R) cells at concentrations higher than 30 nM. | |
| In vivo(体内研究) | Betahistine ( Betahistine (16 mg twice per day for 3 months) has a significant effect on the frequency, intensity and duration of vertigo attacks, associated symptoms and the quality of life also are significantly improved in patients with Meniere's disease. Betahistine-dihydrochloride (16 mg tid and 48 mg tid) shows that the number of attacks per month decreased in both doses over time in Meni鑢e's disease. Betahistine (50 mg/kg) treatment induces symmetrical changes with up-regulation of histidine decarboxylase mRNA in the tuberomammillary nucleus and reduction of N-alpha-methylhistamine labeling in both the tuberomammillary nucleus, the vestibular nuclei complex and nuclei of the inferior olive in brain sections of cats. | |
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Certificate of Analysis(COA)
