Bay K 8644
- (±)-Bay K8644
货号: abs816169
货号-规格 | 货期 | 价格 | 数量 |
abs816169-5mg | 现货 | ¥1087.00 | - + |
abs816169-10mg | 现货 | ¥1737.00 | - + |
abs816169-25mg | 现货 | ¥3492.00 | - + |
abs816169-100mg | 现货 | ¥7762.00 | - + |

产品描述 | ||
描述 | Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | (±)-Bay K8644 | |
外观 | Yellow solid | |
可溶性/溶解性 | DMSO :71mg/mL(199.27mM) Ethanol :71mg/mL(199.27mM) | |
生物活性 | ||
靶点 | L-type calcium channel | |
In vitro(体外研究) | It was demonstrated that Bay K 8644 prolonged the mean Ca2+ channel opening time in heart myocytes and neurones of spinal ganglia. An experiment using rat heart ventricles demonstrated that Bay K 8644, at the final concentration of approximately 1 pM, had strong positive inotropic effect when added to the perfusion fluid. Moreover, the addition of Bay K 8644 to the chronic ethanol treatment significantly reduced the electrophysiological signs of withdrawal in the isolated hippocampal slices. | |
In vivo(体内研究) | Study in mice demonstrated that Bay K 8644 significantly ameliorated the ethanol withdrawal syndrome. When experimental animals were administered with an acute injection of Bay K 8644, the convulsive behavior of mice could be monitored to increase for 2 hours. In addition, BAY k 8644 was also reported to ameliorate hypotension in endotoxin-shocked rats. It could lead to a 37% decrease in heart rate of endotoxin-treated rats and 39% decrease in control rats in a dose-dependent manner. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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