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  • Bay K 8644

    • (±)-Bay K8644
    货号: abs816169
    CAS号: 71145-03-4
    分子式: C16H15F3N2O4
    分子量: 356.30
    产品说明书
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    货号-规格 货期 价格 数量
    abs816169-5mg 现货 ¥1087.00
    - +
    abs816169-10mg 现货 ¥1737.00
    - +
    abs816169-25mg 现货 ¥3492.00
    - +
    abs816169-100mg 现货 ¥7762.00
    - +
    大包装询价
    产品描述
    描述

    Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    (±)-Bay K8644
    外观
    Yellow solid
    可溶性/溶解性
    DMSO :71mg/mL(199.27mM)
    Ethanol :71mg/mL(199.27mM)
    生物活性
    靶点
    L-type calcium channel
    In vitro(体外研究)
    It was demonstrated that Bay K 8644 prolonged the mean Ca2+ channel opening time in heart myocytes and neurones of spinal ganglia. An experiment using rat heart ventricles demonstrated that Bay K 8644, at the final concentration of approximately 1 pM, had strong positive inotropic effect when added to the perfusion fluid. Moreover, the addition of Bay K 8644 to the chronic ethanol treatment significantly reduced the electrophysiological signs of withdrawal in the isolated hippocampal slices.
    In vivo(体内研究)
    Study in mice demonstrated that Bay K 8644 significantly ameliorated the ethanol withdrawal syndrome. When experimental animals were administered with an acute injection of Bay K 8644, the convulsive behavior of mice could be monitored to increase for 2 hours. In addition, BAY k 8644 was also reported to ameliorate hypotension in endotoxin-shocked rats. It could lead to a 37% decrease in heart rate of endotoxin-treated rats and 39% decrease in control rats in a dose-dependent manner.
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