Baicalein
- 黄芩素;5,6,7-Trihydroxyflavone
货号: abs814549
货号-规格 | 货期 | 价格 | 数量 |
abs814549-50mg | 1-2周 | ¥386.00 | - + |
abs814549-100mg | 现货 | ¥551.00 | - + |
abs814549-200mg | 1-2周 | ¥882.00 | - + |

产品描述 | ||
描述 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 黄芩素;5,6,7-Trihydroxyflavone | |
外观 | 淡黄色结晶性粉末 | |
可溶性/溶解性 | DMSO : ≥ 34 mg/mL (125.81 mM) | |
生物活性 | ||
靶点 | XO,CYP2C9 | |
In vitro(体外研究) | Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment. Baicalein suppresses proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes. | |
In vivo(体内研究) | Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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