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  • ARQ 621

    货号: abs817763
    CAS号: 1095253-39-6
    分子式: C28H24Cl2FN5O2
    分子量: 552.43
    产品说明书
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    货号-规格 货期 价格 数量
    abs817763-5mg 1-2周 ¥1552.00
    - +
    abs817763-25mg 1-2周 ¥3881.00
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    大包装询价
    产品描述
    描述
    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO:100 mg/mL (181.01 mM)
    生物活性
    靶点
    Eg5 mitotic motor protein
    In vitro(体外研究)
    ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells.
    In vivo(体内研究)
    ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs.
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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