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  • Apilimod
    • STA 5326; STA5326; STA-5326
    货号: abs810257
    CAS号: 541550-19-0
    分子式: C23H26N6O2
    分子量: 418.49
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810257-5mg 1-2周 ¥1087.00
    - +
    abs810257-10mg 1-2周 ¥1794.00
    - +
    abs810257-50mg 1-2周 ¥5618.00
    - +
    abs810257-100mg 1-2周 ¥9945.00
    - +
    大包装询价
    产品描述
    描述
    Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    STA 5326; STA5326; STA-5326
    外观
    Powder
    可溶性/溶解性
    DMSO: ≥ 46 mg/mL
    生物活性
    靶点
    Interleukin Related
    In vitro(体外研究)
    Apilimod inhibited IFN-γ production induced by either IFN-γ/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM. Apilimod show some inhibition against IFN-γ/SAC-induced TNF-α and ConA-induced IL-5 from human PBMCs at high concentrations, but no suppressive effect against IL-1β, IL-2, IL-4, IL-8, and IL-18 in all cultures tested. The p35 and p40 promoter-driven luciferase activities are significantly induced after stimulation with IFN-γ/LPS or IFN-γ/SAC, and are completely suppressed by 100 nM Apilimod.
    In vivo(体内研究)
    Apilimod (10 mg/kg, p.o.) is effective not only when administered throughout the entire experiment, but also when administration is initiated on day 30 when disease is clearly measurable but not maximal. TA-5326 causes a significant reduction in cell number only in the Th1 model, with an average percentage of inhibition of 51%±8% relative to the vehicle control. Apilimod treatment has no effect in the Th2 setting. Apilimod (5 or 20 mg/kg, p.o.) reduces the level of IL-12 p40 in serum without altering body weight in EAU mice. Oral administration of Apilimod reduces the severity of experimental autoimmune uveoretinitis (EAU) by clinical and histopathological analysis.
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    • 实验方法 实验条件
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