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  • Amlodipine maleate

    • 马来酸氨氯地平;氨氯地平马来酸盐
    货号: abs822920
    CAS号: 88150-47-4
    分子式: C24H29ClN2O9
    分子量: 524.95
    产品说明书
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    货号-规格 货期 价格 数量
    abs822920-1g 1-2周 ¥926.00
    - +
    abs822920-5g 1-2周 ¥2911.00
    - +
    大包装询价
    产品描述
    描述
    Amlodipine maleate is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    马来酸氨氯地平;氨氯地平马来酸盐
    外观
    Off white to light yellow powder
    可溶性/溶解性
    DMSO : 120 mg/mL (228.59 mM; Need ultrasonic)
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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