Aloxistatin
- 阿洛司他丁；E64d; E64c ethyl ester
货号： abs817918
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817918-2mg | 现货 | ￥736.00 | - + |
| abs817918-5mg | 现货 | ￥1171.00 | - + |
| abs817918-25mg | 现货 | ￥4572.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Aloxistatin 是一种不可逆的膜透过性cysteine protease 抑制剂。 | |
| 纯度 | ＞98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 阿洛司他丁；E64d; E64c ethyl ester | |
| 外观 | 白色粉末 | |
| 可溶性/溶解性 | DMSO : 6.9 mg/mL (20 mM) | |
| 生物活性 | ||
| 靶点 | Cysteine protease | |
| In vitro(体外研究) | Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain. Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro. | |
| In vivo(体内研究) | Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters. In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra. Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B activity. | |
| 参考文献 | ||
| 参考文献 | [1] Tamai M, et al. J Pharmacobiodyn. 1986, 9(8), 672-677. [2] Sekiguchi, T., et al. 2002. Zool. Sci. 19: 1251-1255. [3] Yoshifuji, H., et al. 2005. Int. Immunol. 17: 1327-1336. [4] Morimoto, M., et al. 2007. Int. Immunopharmacol. 7: 973-980. [5] Tanabe, F., et al. 2009. Int. Immunopharmacol. 9: 366-370. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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