货号: abs818316
货号-规格 | 货期 | 价格 | 数量 |
abs818316-1mg | 1-2周 | ¥1940.00 | - + |
abs818316-5mg | 1-2周 | ¥5821.00 | - + |

产品描述 | ||
描述 | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. | |
基本信息 | ||
可溶性/溶解性 | DMSO: 15.5 mg/mL | |
生物活性 | ||
靶点 | Eukaryotic Initiation Factor (eIF) | |
In vitro(体外研究) | 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner. | |
In vivo(体内研究) | 4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death. | |
参考文献 | ||
参考文献 | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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