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  • 2-Methoxy-1,4-naphthoquinone

    货号: abs817687
    CAS号: 2348-82-5
    分子式: C11H8O3
    分子量: 188.18461
    产品说明书
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    货号-规格 货期 价格 数量
    abs817687-10mg 1-2周 ¥263.00
    - +
    abs817687-25mg 1-2周 ¥383.00
    - +
    abs817687-50mg 1-2周 ¥568.00
    - +
    abs817687-250mg 1-2周 ¥1092.00
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    大包装询价
    产品描述
    描述
    Lawsone (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    生物活性
    靶点
    PKCβ1 ,PKCδ ,PKCζ
    In vitro(体外研究)
    2-Methoxy-1,4-naphthoquinone (MNQ) exhibits antifungal, antimicrobial activities and showed strong killing effect on K562, HL-60, Raji, MCF-7, H-23, IMR-32, LA-174-T, HSC-2, and SK-MEL-28. MNQ is able to trigger the intrinsic apoptotic pathway in K562 cells, as well as causing p53-dependent cell cycle arrest in the p53-wild type cell line. MNQ inhibits the TCF/β-catenin (TOP) transcriptional activity at IC50 2.9 μM, while it decreases the transcriptional activity of FOP (mutated TCF-binding site)-transfected cell. MNQ exerts an anti-metastatic effect against MDA-MB-231 cells. MNQ has remarkable selectivity towards PKCβI and ζ suppression. MNQ suppresses PKCδ moderately, where MNQ suppresses half of the PKCδ expression at the concentration of 10 μM. MNQ does not suppress PKC βII. MNQ is able to inhibit the invasion and migration characteristics of a highly metastatic MDA-MB-231 cancer cell line.
    参考文献
    参考文献
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