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  • U0126

    促销商品
    • U0126;U 0126
    货号: abs810003
    CAS号: 109511-58-2
    分子式: C18H16N6S2
    分子量: 380.48
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810003-5mg 现货 ¥441.00 ¥397.00
    - +
    abs810003-10mg 1-2周 ¥662.00
    - +
    abs810003-25mg 现货 ¥1323.00 ¥1191.00
    - +
    abs810003-50mg 现货 ¥2205.00 ¥1985.00
    - +
    abs810003-100mg 现货 ¥3528.00 ¥3175.00
    - +
    大包装询价
    产品描述
    描述

    U-0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    U0126;U 0126
    外观
    Lyophilized powder
    可溶性/溶解性
    Soluble in DMSO at 200 mg/mL
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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