Streptozocin

miR‐590‐3p suppresses differentiation and collagen synthesis in HCFs. The mRNA (A) and protein (B) expression of α‐SMA in HCFs transfected with miR‐590‐3p mimics or miR‐590‐3p inhibitor. The mRNA (C) and protein (D) expression of Col1A1 and Col3A1 in HCFs transfected with miR‐590‐3p mimics or miR‐590‐3p. *Indicates P < .05. **Indicates P < .01. Indicates P > .05. Data are shown as mean ± SD. NC: negative control

miR‐590‐3p suppresses the differentiation and collagen synthesis by targeting ZEB1. Effect of interfering with the expression of ZEB1 on the mRNAs (A) and protein (B) levels of α‐SMA. Effect of interfering with the expression of ZEB1 on the mRNAs (C) and protein (D) levels of Col1A1 and Col3A1. Data are shown as mean ± SD. *Indicates P < .05. **Indicates P < .01. NC: negative control. SiZEB1: small interfering RNA for ZEB1 gene

Expression of miR‐590‐3p and ZEB1 in MI model of pigs. A, Expression of miR‐590‐3p at infarct area in control and MI pigs. The mRNA (B) and protein (C) expression levels of ZEB1 at infarct area in control and MI pigs. Data are shown as mean ± SD. *Indicates P < .05. **Indicates P < .01