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  • Sodium orthovanadate
  • 原钒酸钠;正钒酸钠
  • 货号: abs817431
    CAS号: 13721-39-6
    分子式: Na3O4V
    分子量: 183.9
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    货号-规格 货期 价格 数量
    abs817431-100mg 现货 ¥305.00
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    abs817431-500mg 现货 ¥735.00
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    ! 该货号为 abs47027936 的新货号。
    大包装询价
    产品描述
    描述

    Sodium orthovanadate is a commonly used general inhibitor for PTP (protein tyrosine phosphatases), alkaline phosphatase (ALP) and ATPase. Na3VO4 acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by Fluoride and EDTA. Vanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays. Sodium Orthovanadate is an inhibitor of AK and PFK.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    原钒酸钠;正钒酸钠
    外观
    类白色固体
    可溶性/溶解性
    Soluble in DMSO, water, ethanol
    生物活性
    靶点
    (Na,K)-ATPase
    In vitro(体外研究)
    In transient forebrain ischemia, Sodium orthovanadate rescues cells from delayed neuronal death in the hippocampal CA1 region. The neuroprotective effects of Sodium orthovanadate and IGF-1 are associated with preventing decreased Akt-Ser-473 phosphorylation in the CA1 region observed immediately after reperfusion. Akt is moderately activated in the cell bodies and dendrites of pyramidal neurons after orthovanadate treatment. The Sodium orthovanadate treatment also prevents the decrease in phosphorylation of mitogen-activated protein kinase (MAPK). Sodium orthovanadate inhibits ASK1 through the PI3-K/Akt-dependent pathway. Sodium orthovanadate up-regulates Akt activity in the brain and in turn rescue neurons from delayed neuronal death by inhibiting FKHR-dependent or -independent death signals in neurons.
    In vivo(体内研究)
    In a rat model of myocardial ischemic infarction, sodium orthovanadate rescues cells from ischemia/reperfusion injuries. Post-treatment with Sodium orthovanadate reduces infarct size in a dose-dependent manner. Sodium orthovanadate treatment also ameliorates contractile dysfunction of the left ventricle 72 hours after reperfusion. The cytoprotective action of Sodium orthovanadate treatment is closely associated with inhibition of fodrin breakdown. Sodium orthovanadate treatment inhibits caspase-3 activation induced by ischemia.
    参考文献
    参考文献
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