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  • SB202190 (FHPI)

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    • SB202190;SB-202190
    货号: abs810009
    CAS号: 152121-30-7
    分子式: C20H14FN3O
    分子量: 331.35
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    货号-规格 货期 价格 数量
    abs810009-5mg 现货 ¥331.00 ¥99.00
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    abs810009-50mg 现货 ¥1191.00
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    大包装询价
    产品描述
    描述

    SB202190(FHPI)是一种有效的p38MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。

    纯度
    >98 %
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    SB202190;SB-202190
    外观
    Lyophilized powder
    可溶性/溶解性
    DMSO :66 mg/mL (199.19 mM)

    Ethanol :12 mg/mL (36.21 mM)
    生物活性
    靶点
    p38α;p38β
    In vitro(体外研究)
    SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. SB 202190 treatment inhibits the expression of albumin-induced proinflammatory (monocyte chemoattractant protein-1) and transforming growth factor (TGF)-beta1-induced profibrotic (procollagen-Ialpha1) genes over 50% in renal tubular cells (normal rat kidney-52E). SB 202190 treatment induces phosphorylation of JNK in a dose- and time- dependent manner in A549 cells, induces phosphorylation of ATF-2 transcription factor, and increases AP-1 DNA binding. SB 202190 treatment enhances the growth of THP-1 and MV4-11 cells. SB 202190 increases the phosphorylation of c-Raf and ERK, suggesting that Ras-Raf-MEK-mitogen-activated protein kinase (MAPK) pathway activation is involved in the leukemia cell growth induced by SB 202190.
    In vivo(体内研究)
    Inhibiting p38 by administration of SB 202190 inhibits PV IgG-induced blister formation in the passive transfer mouse model. In the endotoxin model of sepsis, SB 202190 treatment produces a statistically significant survival benefit compared with control.
    参考文献
    参考文献
    [1] Davies SP, et al. Biochem J, 2000, 351(Pt 1), 95-105.
    [2] Nemoto S, et al. J Biol Chem, 1998, 273(26), 16415-16420.
    [3] Chen W, et al. Oncogene, 2001, 20(29), 3921-3926.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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