SB202190 (FHPI)
爱闪购- SB202190;SB-202190
货号: abs810009
货号-规格 | 货期 | 价格 | 数量 |
abs810009-5mg | 现货 | - + | |
abs810009-50mg | 现货 | ¥1191.00 | - + |

产品描述 | ||
描述 | SB202190(FHPI)是一种有效的p38MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。 | |
纯度 | >98 % | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | SB202190;SB-202190 | |
外观 | Lyophilized powder | |
可溶性/溶解性 | DMSO :66 mg/mL (199.19 mM) Ethanol :12 mg/mL (36.21 mM) | |
生物活性 | ||
靶点 | p38α;p38β | |
In vitro(体外研究) | SB 202190 significantly inhibits both basal and anti-Fas antibody-induced MAPKAPK 2 activity in a dose-dependent manner. SB202190 by itself is sufficient to induce cell death in Jurkat and HeLa cells through activation of CPP32-like caspases, which can be blocked by expression of bcl-2. SB202190-induced apoptosis is attenuated by p38β but augmented by p38α. SB 202190 strongly inhibits UVB induced COX-2 protein expression in HaCaT cells, and markedly inhibits UVB induced cox-2 mRNA. SB 202190 treatment inhibits the expression of albumin-induced proinflammatory (monocyte chemoattractant protein-1) and transforming growth factor (TGF)-beta1-induced profibrotic (procollagen-Ialpha1) genes over 50% in renal tubular cells (normal rat kidney-52E). SB 202190 treatment induces phosphorylation of JNK in a dose- and time- dependent manner in A549 cells, induces phosphorylation of ATF-2 transcription factor, and increases AP-1 DNA binding. SB 202190 treatment enhances the growth of THP-1 and MV4-11 cells. SB 202190 increases the phosphorylation of c-Raf and ERK, suggesting that Ras-Raf-MEK-mitogen-activated protein kinase (MAPK) pathway activation is involved in the leukemia cell growth induced by SB 202190. | |
In vivo(体内研究) | Inhibiting p38 by administration of SB 202190 inhibits PV IgG-induced blister formation in the passive transfer mouse model. In the endotoxin model of sepsis, SB 202190 treatment produces a statistically significant survival benefit compared with control. | |
参考文献 | ||
参考文献 | [1] Davies SP, et al. Biochem J, 2000, 351(Pt 1), 95-105.
[2] Nemoto S, et al. J Biol Chem, 1998, 273(26), 16415-16420. [3] Chen W, et al. Oncogene, 2001, 20(29), 3921-3926. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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