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  • Recombinant SARS-CoV-2 S-trimer Protein C-6His

    • 2019-nCoV S-trimer蛋白;2019-nCov S protein, 2019-nCoV Spike glycoprotein, 2019-nCoV S glycoprotein
    货号: abs04710
    产品说明书
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    货号-规格 货期 价格 数量
    abs04710-50ug 1-2周 ¥2625.00
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    大包装询价
    概述
    描述
    Recombinant 2019-nCoV S-trimer Protein is produced by our Mammalian expression system with a 6His tag at the C-terminus.
    别名
    2019-nCoV S-trimer蛋白;2019-nCov S protein, 2019-nCoV Spike glycoprotein, 2019-nCoV S glycoprotein
    种属
    SARS-CoV-2
    来源
    Mammalian
    分子量
    Mol Mass: 136.6kDa AP Mol Mass: 170-220kDa, reducing conditions
    形态
    Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
    性能
    标签
    C-6His
    纯化方法
    Affinity purification chromatography.
    纯度
    Greater than 95% as determined by reducing SDS-PAGE
    内毒素水平
    Less than 1 EU per μg by the LAL method.
    标记
    unconjugated
    储存/保存方法
    6 months from date of receipt,-20℃ to -70℃ as supplied.avoid repeated freeze-thaw cycles.
    靶标
    背景说明
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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