JK184
- JK 184;JK-184;Hh Signaling Antagonist VII
货号: abs814562
货号-规格 | 货期 | 价格 | 数量 |
abs814562-5mg | 1-2周 | ¥582.00 | - + |
abs814562-10mg | 1-2周 | ¥922.00 | - + |
abs814562-25mg | 1-2周 | ¥2199.00 | - + |
abs814562-50mg | 1-2周 | ¥3638.00 | - + |

产品描述 | ||
描述 | JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
形态 | Solid | |
基本信息 | ||
别名 | JK 184;JK-184;Hh Signaling Antagonist VII | |
外观 | off-white to light brown powder | |
密度 | ~1.3 g/cm3 (Predicted) | |
折射率 | n20D 1.68 (Predicted) | |
IC50 | enzymatic activity of Adh7: IC50 = 210 nM; Hg-Ag-induced Gli-transcription activity : IC50 = 30 nM; sonic hedgehog induced Gli transcription: IC50 = 30 nM | |
可溶性/溶解性 | DMSO : ≥ 50 mg/mL (142.68 mM) | |
PubChem CID | 1069686 | |
生物活性 | ||
靶点 | Hedgehog | |
In vitro(体外研究) | JK184 is designed to antagonize Hh signaling by inhibiting glioma (Gli)-dependent transcriptional activity in a dose dependent manner. JK184 significantly inhibitts proliferation of HUVECs with IC50 of 6.3 μg/mL after three days incubation. To evaluate anti-tumor effect of JK184, MTT assay is conducted in Panc-1 and BxPC-3 cells after administration with indicated concentrations of compounds, half maximal inhibitory concentration (IC50) of JK184 (23.7 ng/mL in anc-1 and 34.3 ng/mL in BxPC-3). Claudin-low cell lines are more sensitive to JK184 treatment than are MCF10a, MTSV1-7, or HMLE-shGFP and HMLE-pBP cells, and JK184 induced a dose-dependent decrease in glioma-associated oncogene homolog 1 (GLI1) transcript and protein levels in these cells. Treatment with the IC50 dose of JK184 enhances the proportion of HMLE-shEcad cells that stained with Annexin-V, but are negative for propidium iodide (PI) (P<0.0001, t test). | |
In vivo(体内研究) | JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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