- IACS-10759
货号: abs814544
货号-规格 | 货期 | 价格 | 数量 |
abs814544-5mg | 现货 | ¥1323.00 | - + |
abs814544-25mg | 现货 | ¥4300.00 | - + |
abs814544-50mg | 现货 | ¥8159.00 | - + |

产品描述 | ||
描述 | IACS-010759 is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I. | |
纯度 | 98% | |
储存/保存方法 | store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. | |
基本信息 | ||
别名 | IACS-10759 | |
外观 | powder | |
可溶性/溶解性 | DMSO :27 mg/mL (47.99 mM) | |
生物活性 | ||
靶点 | oxidative phosphorylation,OXPHOS | |
In vitro(体外研究) | IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations. | |
In vivo(体内研究) | IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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