- IACS-10759
货号： abs814544
| 货号-规格 | 货期 | 价格 | 数量 |
| abs814544-5mg | 现货 | ￥1323.00 | - + |
| abs814544-25mg | 现货 | ￥4300.00 | - + |
| abs814544-50mg | 现货 | ￥8159.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | IACS-010759 is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I. | |
| 纯度 | 98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. | |
| 基本信息 | ||
| 别名 | IACS-10759 | |
| 外观 | powder | |
| 可溶性/溶解性 | DMSO ：27 mg/mL (47.99 mM) | |
| 生物活性 | ||
| 靶点 | oxidative phosphorylation,OXPHOS | |
| In vitro(体外研究) | IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations. | |
| In vivo(体内研究) | IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
