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  • Homatropine Bromide

    • 氢溴酸后马托品;Homatropine hydrobromide
    货号: abs813673
    CAS号: 51-56-9
    分子式: C16H21NO3.HBr
    分子量: 356.25
    产品说明书
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    货号-规格 货期 价格 数量
    abs813673-100mg 1-2周 ¥551.00
    - +
    abs813673-200mg 1-2周 ¥938.00
    - +
    abs813673-500mg 1-2周 ¥1709.00
    - +
    大包装询价
    产品描述
    描述

    Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    氢溴酸后马托品;Homatropine hydrobromide
    外观
    类白色粉末
    可溶性/溶解性
    DMSO :66 mg/mL (185.3 mM)

    Water :65 mg/mL (182.5 mM)
    生物活性
    靶点
    mAChR (WKY-E),mAChR (SHR-E)
    In vitro(体外研究)
    Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.
    In vivo(体内研究)
    Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. Homatropine methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure.
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    • 实验方法 实验条件
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