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  • GPR120 Compound A

    • GPR120 cpdA;GPR120-IN-1;MDK-77754; MDK 77754;GPR120 Agonist 3
    货号: abs814165
    CAS号: 1599477-75-4
    分子式: C19H23ClF3NO3
    分子量: 405.8
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    货号-规格 货期 价格 数量
    abs814165-10mg 现货 ¥1985.00
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    abs814165-25mg 现货 ¥4167.00
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    大包装询价
    产品描述
    描述

    GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 μm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    GPR120 cpdA;GPR120-IN-1;MDK-77754; MDK 77754;GPR120 Agonist 3
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 50 mg/mL (123.20 mM)
    生物活性
    靶点
    GPR120
    In vitro(体外研究)
    GPR120-IN-1 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120-IN-1 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation .
    In vivo(体内研究)
    GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten.
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