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  • Finasteride
  • 非那雄胺;非那斯特萊;MK-906
  • 货号: abs817943
    CAS号: 98319-26-7
    分子式: C23H36N2O2
    分子量: 372.54
    产品说明书
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    货号-规格 货期 价格 数量
    abs817943-25mg 1-2周 ¥310.00
    - +
    abs817943-50mg 1-2周 ¥441.00
    - +
    abs817943-100mg 1-2周 ¥546.00
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    大包装询价
    产品描述
    描述

    Finasteride是一种有效的睾酮5α-还原酶抑制剂,Ki为10 nM。

    纯度
    99%
    储存/保存方法
    Store at -20°C
    基本信息
    别名
    非那雄胺;非那斯特萊;MK-906
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    DMSO : 37.3 mg/mL (100 mM)

    Ethanol : 37.3 mg/mL (100 mM)
    生物活性
    靶点
    5-α reductase
    In vitro(体外研究)
    Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 1.62 ms. Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells.
    In vivo(体内研究)
    Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. Finasteride also causes decreased anogenital distance in male offspring in male rats. Finasteride and castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats. Finasteride-induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to control values by day 9 in rats.
    参考文献
    参考文献
    [1] Azzolina B, et al. J Steroid Biochem Mol Biol, 1997, 61(1-2), 55-64.
    [2] Gao, W. et al. 2004. Endocrinology. 145(12): 5420-5428.
    [3] Mukai, Y. et al. 2008. Biol. Pharm. Bull. 31(9): 1646-1650.
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