Encequidar mesylate
- HM30181 mesylate;HM30181A mesylate
货号: abs822818
货号-规格 | 货期 | 价格 | 数量 |
abs822818-5mg | 1-2周 | ¥1050.00 | - + |
abs822818-50mg | 1-2周 | ¥5150.00 | - + |

产品描述 | ||
描述 | Encequidar (mesylate) (HM30181 (mesylate)) is a competitive and potent P-glycoprotein inhibitor. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | HM30181 mesylate;HM30181A mesylate | |
外观 | Yellow powder | |
可溶性/溶解性 | DMSO : 25 mg/mL (31.85 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | P-glycoprotein. | |
In vitro(体外研究) | Treatment of 0.1 or 1 nM Encequidar (HM30181) lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively. | |
In vivo(体内研究) | The plasma concentrations of Encequidar (HM30181) are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar (HM30181) in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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