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  • Dorzolamide hydrochloride

    • 盐酸多佐胺;L671152 hydrochloride;MK507 hydrochloride
    货号: abs817410
    CAS号: 130693-82-2
    分子式: C10H17ClN2O4S3
    分子量: 360.9
    产品说明书
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    货号-规格 货期 价格 数量
    abs817410-5mg 1-2周 ¥783.00
    - +
    abs817410-10mg 1-2周 ¥1406.00
    - +
    abs817410-20mg 1-2周 ¥1830.00
    - +
    abs817410-50mg 1-2周 ¥2536.00
    - +
    大包装询价
    产品描述
    描述

    Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    盐酸多佐胺;L671152 hydrochloride;MK507 hydrochloride
    外观
    白色粉末
    可溶性/溶解性
    Water : 12 mg/mL (33.3 mM)
    生物活性
    靶点
    Carbonic anhydrase II,Carbonic anhydrase IV,Carbonic anhydrase I
    In vitro(体外研究)
    Dorzolamide is a powerful inhibitor of carbonic anhydrase (CA) II that penetrates the sclera and cornea to reach the ciliary process and lowers formation of HCO3 and aqueous humor. Dorzolamide causes a vasodilatation of retinal arteries, pre-contracted by three different mechanisms by direct action and presumably independent of changes in extracellular pH.
    In vivo(体内研究)
    Dorzolamide, administered twice and three times daily, significantly decreases intraocular pressure (IOP) in glaucomatous dogs on the first day (twice daily 7.6 mmHg, and three times daily 16.4 mmHg) that is even greater by day 5 (twice daily 10.4 mmHg, and three times daily 13.9 mmHg). Dorzolamide (instilled in the drug eye for day 1 through to day 5) combined with oral methazolamide (administered from day 3 through to day 5) significantly lowers IOP in the eye on day 1, for day 3 and for all of day 5 for both eyes. Dorzolamide (2%) instilled three times daily produces similar IOP declines compared to the combination of oral methazolamide and 2% dorzolamide administered twice daily. Dorzolamide hydrochloride induces a very large IOP reduction and is found to be also well effective at night in rabbit. Dorzolamide maximally lowers the intraocular pressure (IOP) of glaucomatous monkeys by 22%, 30% and 37%, respectively.
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    参考文献
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