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  • Dorsomorphin free base

    • BML-275; Compound C; BML275; BML 275
    货号: abs810530
    CAS号: 866405-64-3
    分子式: C24H25N5O
    分子量: 399.49
    产品说明书
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    货号-规格 货期 价格 数量
    abs810530-5mg 1-2周 ¥679.00
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    abs810530-50mg 现货 ¥3742.00
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    大包装询价
    产品描述
    描述

    Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    BML-275; Compound C; BML275; BML 275
    外观
    white to beige Powder
    可溶性/溶解性
    DMSO : 3 mg/mL (7.5 mM), warmed

    Ethanol : 2 mg/mL (5.0 mM), warmed
    生物活性
    靶点
    AMPK
    In vitro(体外研究)
    Dorsomorphin inhibits ACC inactivation by either AICAR or metformin, and also attenuates AICAR and metformin’s effect to increase fatty acid oxidation or suppress lipogenic genes in hepatocytes. Inhibition of AMPK activity by Dorsomorphin almost completely inhibits autophagic proteolysis in HT-29 cells. in addition, Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6, and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.
    In vivo(体内研究)
    Dorsomorphin (10 mg/kg) reduces basal levels of hepcidin expression and increases serum iron concentrations in adult mice. Dorsomorphin (0.2 mg/kg, i.v.) significantly reduces VCAM-1 and ICAM-1 expression in the thoracic aorta of LPS-treated rats.
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